BioNano Genomics has patented a method for analyzing nucleic acid molecules without compromising strand integrity. The method involves covalently labeling DNA repeated motifs with a detectable tag, allowing for the identification of patterns without disrupting the phosphodiester bonds. GlobalData’s report on BioNano Genomics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on BioNano Genomics, Microfluidic devices was a key innovation area identified from patents. BioNano Genomics's grant share as of April 2024 was 32%. Grant share is based on the ratio of number of grants to total number of patents.

Nucleic acid molecule analysis method with intact phosphodiester bonds

Source: United States Patent and Trademark Office (USPTO). Credit: BioNano Genomics Inc

A recently granted patent (Publication Number: US11959134B2) discloses a method for analyzing nucleic acid molecules while maintaining the integrity of the strand phosphodiester bonds. The method involves providing a group of nucleic acid molecules containing DNA repeated motifs, covalently labeling them in a sequence-specific manner using a methyltransferase and a modified cofactor, and detecting the label to identify patterns of the DNA repeated motifs. The labeled nucleic acid molecules must have a length of at least 150 kb, and the strand phosphodiester bonds must remain intact throughout the process. The patterns identified can include CpG island methylation patterns, histone modifications, structural variations, nucleosomal remodeling, pathogen-specific patterns, or a combination thereof.

Furthermore, the method allows for the detection of the density and CpG methylation status of the DNA repeat motifs on the nucleic acid molecules. The covalent labeling can be done in a CpG-methylation-insensitive or CpG-methylation-dependent manner, with the use of various tags such as fluorophores, quantum dots, dendrimers, and more. The identified patterns of the DNA repeated motifs can provide insights into physiological conditions or diseases associated with the CpG methylation status and repeat frequency of the DNA motifs. Additionally, the method involves assembling the identified patterns into genomic maps and comparing them to reference genomes through in silico analysis, offering a comprehensive understanding of the nucleic acid molecules' characteristics and potential implications.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.