Harvard Bioscience. has been granted a patent for a synthetic tissue or organ scaffold designed to maintain structural integrity and prevent damage during implantation. The scaffold features a conductive support structure, electrospun nanofiber layers, and a stretchable sheath, enhancing stability and functionality. GlobalData’s report on Harvard Bioscience gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Harvard Bioscience, was a key innovation area identified from patents. Harvard Bioscience's grant share as of June 2024 was 52%. Grant share is based on the ratio of number of grants to total number of patents.
Synthetic tissue scaffolds with electrospun fibers and conductive support
The patent US12042369B2 describes a novel structure designed for applications in synthetic organ support, featuring a tubular conductive support structure and an overlaying tubular layer composed of electrospun nanofibers. These nanofibers contain particles that dissolve upon contact with a solvent, creating pores within the tubular layer. The structure also includes a woven, stretchable sheath made from a polymeric material, which is positioned radially inward of the tubular layer. This sheath is elastic, allowing it to be removable and deformable in one direction, thereby protecting the integrity of the tubular layer while facilitating electrical conductivity between the conductive support and the tubular layer.
The claims further detail the capabilities of the conductive support structure, which can be selectively electrically charged to influence the bonding properties of the nanofiber layers. This charge can be controlled to achieve various deposition characteristics of the nanofibers, resulting in specific mechanical and biological properties tailored for synthetic organ applications. The structure allows for the integration of micro and nano features in the nanofiber layers, enhancing their functionality. Additionally, methods for modifying the structural properties of the scaffold through flexing or exercising during synthesis are also outlined, potentially impacting the bending radius and overall performance of the scaffold. The patent emphasizes the innovative combination of materials and methods to create a versatile and functional support structure for synthetic organs.
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