Standard BioTools has been granted a patent for a method to detect and quantify target proteins in biological samples. The method involves capturing proteins with aptamers, sequencing them using next-generation techniques, and determining protein abundances based on the obtained data. GlobalData’s report on Standard BioTools gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Standard BioTools, Microfluidic devices was a key innovation area identified from patents. Standard BioTools's grant share as of May 2024 was 36%. Grant share is based on the ratio of number of grants to total number of patents.
Method for quantifying target proteins in biological samples
A recently granted patent (Publication Number: US11965880B2) outlines a method for quantifying the abundances of target proteins in a biological sample. The method involves capturing target proteins using aptamers, isolating the captured aptamers, forming tri-molecular complexes with capture probes, amplifying aptamer ID sequences, sequencing them via next-generation sequencing, and determining protein abundances based on the obtained data. The aptamers used in the method have a specific rate of protein-aptamer dissociation, and the process includes various steps such as dividing eluates and capture probes into groups, amplifying different subsets of sequences, and adding quantitative spike reporters for accuracy.
Furthermore, the patent also describes a method for quantifying the abundances of multiple species of target proteins in a biological sample. This method involves capturing target proteins with aptamers, forming tri-molecular complexes, amplifying aptamer ID sequences, sequencing them, and quantifying protein abundances based on the sequenced data. Similar to the previous method, this approach includes steps like dividing eluates into dilution groups, amplifying different subsets of sequences in aliquots, and adding quantitative spike reporters. The sequencing of aptamer ID sequences is done via next-generation sequencing, and the aptamers used in this method also have chemically modified nucleotides for enhanced performance. Additionally, a method for detecting a target protein in a biological sample is outlined, involving capturing the protein with an aptamer, forming tri-molecular complexes, amplifying aptamer ID sequences, and sequencing them to identify the captured aptamer and target protein. This method includes determining boundaries for probes based on desired melting temperatures and dissociating the probe from the aptamer before amplification for accurate results.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
