The NPi®-300 Pupillometer is an accurate, reliable and objective system to measure pupil size and reactivity in patients. Credit: NeurOptics.
The barcode reader incorporated into the system allows physicians to scan new patients' IDs accurately and instantly. Credit: NeurOptics.
The NPi-300 Pupillometer improves pupillary evaluation to assist in detecting brain injury, treatment and prognosis. Credit: NeurOptics.

NeurOptics’ NPi®-300 Pupillometer is a handheld optical scanner that measures pupil size and reactivity in patients, supporting enhanced neurological pupillary examinations to diagnose a broad spectrum of neurological conditions such as traumatic brain injuries, strokes and seizures in adult and paediatric patients.

The NPi-300 Pupillometer is a next-generation automated medical device that advances pupillary evaluation to help physicians diagnose brain injury, guide treatment and inform prognosis.

Launched in July 2021, the NPi-300 Pupillometer complies with Part 15 of the Federal Communications Commission (FCC) Rules. The device is only intended for use by properly trained clinical professionals under the supervision of a qualified physician. Results of NPi-300 scans can serve information purposes but cannot be utilised for clinical diagnostic purposes.

NPi-300 Pupillometer design and specifications

The NPi-300 Pupillometer system contains an NPi-300 Pupillometer, charging station, power adapter and plug.

The state-of-the-art pupillometer features a durable, ergonomic design, modern user interface, upgraded keypad, incorporated barcode scanner and enhanced wireless charging technology.

The NPI-300 Pupillometer’s modern graphical user interface features simple and intuitive icon-based navigation, with an easy-to-read liquid crystal display (LCD) touchscreen to make the results screen more easily visible. The upgraded keypad has easy-to-press keys designed to be used with or without gloves for quick and simple navigation. The barcode scanner enables physicians to scan patients’ IDs accurately and instantly.

The device provides clinicians with quantitative infrared technology, featuring high-precision optics, a processor and an LED light source so that pupil size and reactivity can be measured objectively and accurately in critically ill patients.

The automated NPi-300 Pupillometer eliminates the variability and subjectivity of manual pupillary assessment performed with a penlight, resulting in more accurate, reliable and objective assessment of pupil size and reactivity for neurological examinations.

Neurological Pupil index (NPi®) scale

Automated pupillometry has emerged as a significant technique for quantitative assessment of pupil size and reactivity, measured as the Neurological Pupil index (NPi). The NPi scale ranges from 0 to 4.9, with scores lower than three considered abnormal.

According to the NPi algorithm, a difference of 0.7 in NPi between right and left pupils is also considered an abnormal pupil reading.


SmartGuard® is used once for a patient to associate the patient ID, which is then permanently saved on the SmartGuard. It features smart-card technology that allows patient data to be uploaded into an electronic medical record (EMR) system. Patient information is saved in the SmartGuard memory.

The SmartGuard reader extracts and uploads patient data from SmartGuard automatically. The reader can be used at any nursing terminal or station using a simple universal serial bus (USB) connection. The patient data can be deactivated in line with Health Insurance Portability and Accountability Act (HIPAA) guidelines and facility policies.

Benefits of the NPi-300 Pupillometer

The NPi-300’s completely enclosed wireless charging system improves the reliability and ease of charging. It can be easily cleaned with hospital cleaning agents.

The system allows clinicians to scan a new one-dimensional (1D) or two-dimensional (2D) patient ID accurately, instantly and easily.

The NPi-300’s texturised plastic ergonomic handle design improves grip and helps to reduce dropping and discolouration.

By uploading information into any hospital EMR system utilising the SmartGuard reader, clinicians can minimise the risk of data input error and save nursing time.