Pacific Biosciences of California has been granted a patent for labeled nucleotide analogs that enhance fluorescence-based analytical methods, including single molecule real-time nucleic acid sequencing reactions. The analogs contain components that improve sensitivity, decrease photodamage, and enhance kinetic properties. The patent also covers related compounds, intermediates, and methods of synthesis. GlobalData’s report on Pacific Biosciences of California gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pacific Biosciences of California, Optoelectronic biosensors was a key innovation area identified from patents. Pacific Biosciences of California's grant share as of May 2024 was 37%. Grant share is based on the ratio of number of grants to total number of patents.
Labeled nucleotide analogs for fluorescence-based analytical methods
A recently granted patent (Publication Number: US12000000B2) discloses a labeled nucleotide analog comprising a first avidin protein with four subunits, each containing a biotin binding site, a first nucleotide compound, and a first dye-labeled compound. The first dye-labeled compound is structurally defined and bound to the avidin protein. Additionally, the patent includes claims for variations in the composition, such as the inclusion of a second avidin protein and nucleotide compound, different types of avidin proteins, fluorescent dyes, and specific structural elements within the dye-labeled compound.
Furthermore, the patent claims cover aspects related to the shield element in the dye-labeled compound, comprising various side chains with specific characteristics to enhance the performance of the analog. The presence of terminal coupling elements, biotin moieties, and cyanine dyes are also highlighted in the claims. The patent emphasizes the structural composition and binding mechanisms of the labeled nucleotide analog, aiming to provide a detailed framework for its production and application in various biological processes.
To know more about GlobalData’s detailed insights on Pacific Biosciences of California, buy the report here.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
