US-based Sequel Med Tech has introduced its Tidepool-powered twiist automated insulin delivery (AID) system across the country.
Following clearance by the US Food and Drug Administration (FDA) in 2024 and a period of controlled release, the system is now fully available to clinicians and people with diabetes nationwide.
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The twiist AID system is said to be the first to directly measure insulin volume with every microdose. It uses Sequel’s iiSure Technology to detect delivery issues and alert users up to nine times faster than other systems.
It is cleared for individuals aged six years and above with type 1 diabetes and enables adjustment of basal insulin based on individual dosing needs.
Powered by the twiist Loop algorithm, developed from community-based Tidepool Loop, the system automatically modifies basal insulin delivery using continuous glucose monitor (CGM) data, personal settings, and predicted levels of glucose.
twiist is currently integrated with Abbott’s FreeStyle Libre 3 Plus sensor and Senseonics’ Eversense 365 implantable CGM.
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By GlobalDataFurther integrations are planned by year-end, including Abbott’s anticipated dual glucose-ketone sensor and the DBLG2 algorithm of Diabeloop. These additions aim to increase user choice within an open AID platform.
Sequel CEO and co-founder Alan Lotvin said: “With twiist now accessible to more people than ever before, we’ve reached a meaningful milestone for Sequel and for people living with type 1 diabetes.
“twiist was built to fit into real life, combining precise insulin delivery, an advanced algorithm, and a user experience shaped by the lived experience of people with diabetes. The result is automated insulin delivery designed to deliver the benefits of automation with precision while creating greater personalisation and choice.”
