French firm Defymed has developed a new insulin delivery device ExOlin to facilitate better disease management for both type 1 and type 2 diabetes patients.
ExOlin consists of a biocompatible membrane that is non-biodegradable and permeable to insulin.
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The device is designed as an abdominal implant and allows delivery of insulin to a physiological site when injected through the skin, in contrast to other tools such as pens and external pumps involving subcutaneous delivery.
It is expected that the new delivery device will enable stabilisation of blood sugar levels in the long-term while allowing continuation of conventional injections methods.
Defymed CEO and founder Dr Séverine Sigrist said: “With ExOlin, Defymed shall offer diabetic patients a more physiological approach for delivering insulin. The therapeutic effectiveness of the treatment should thus be significantly improved.
“The patient should also benefit from greater stability in their blood sugar levels and therefore a better quality of life.”
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By GlobalDataThe firm intends to commence the clinical evaluation of ExOlin next year in eight European patients, with plans to commercialise the device in the country by the end of 2020 after obtaining CE Mark.
Defymed will later apply for an approval from the US Food and Drug Administration (FDA) and seeks to raise €10m to support the process of clinical development.
In addition to diabetes management, ExOlin has the potential to be adapted for other applications and pathologies that require a physiological method to deliver drugs or active ingredients.
