10X Genomics has patented a method for creating capture probes on a substrate to pinpoint analyte locations in biological samples. By immobilizing primers on a substrate, hybridizing template oligonucleotides, and releasing them, a spatial array is generated for precise identification. GlobalData’s report on 10X Genomics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on 10X Genomics, ChIP-seq sequencing was a key innovation area identified from patents. 10X Genomics's grant share as of February 2024 was 32%. Grant share is based on the ratio of number of grants to total number of patents.

Generating spatial array of capture probes on substrate

Source: United States Patent and Trademark Office (USPTO). Credit: 10X Genomics Inc

A recently granted patent (Publication Number: US11926867B2) discloses a method for generating a spatial array on a substrate. The method involves immobilizing two sets of primers on the substrate, with one set containing functional domains and a sequence complementary to a hybridization domain, while the other set contains a sequence complementary to a capture domain. A template oligonucleotide with specific domains is then provided, which hybridizes to the first set of primers, leading to the generation of a capture probe. The template oligonucleotide is then released, resulting in the formation of the spatial array.

Furthermore, the method includes amplifying the capture probe to create a clonal cluster of capture probes. This amplification process involves hybridization, extension, and releasing steps to generate multiple copies of the template oligonucleotide immobilized on the substrate. The method also incorporates unique molecular identifiers (UMIs) in the template oligonucleotide for sequencing purposes. The patent covers various aspects of the method, including primer immobilization ratios, primer distances, bead attachment, substrate composition, and sequencing techniques for determining the spatial barcode sequence of the generated capture probes. The disclosed method offers a novel approach to spatial array generation with potential applications in molecular biology research and diagnostics.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.