Exact Sciences. has filed a patent for methods and systems to purify sulfonated DNA using silica supports and acidic conditions. The claim involves combining sulfonated DNA with a silica support in an acidic binding solution to bind the DNA to the support. GlobalData’s report on Exact Sciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Exact Sciences, Personalized medicine biomarkers was a key innovation area identified from patents. Exact Sciences's grant share as of January 2024 was 43%. Grant share is based on the ratio of number of grants to total number of patents.
Purification of sulfonated dna using silica support
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A patent application (Publication Number: US20240026341A1) describes a method for combining sulfonated DNA with a silica support in an acidic binding solution with a pH lower than or equal to the isoelectric point of the sulfonated DNA. The sulfonated DNA is then bound to the silica support, with the option of using different forms of silica support such as particles, beads, fibers, or magnetic particles. The method involves various characteristics of the acidic binding solution, including specific pH ranges, buffer solutions, and chaotropic salts, to facilitate the binding process effectively.
Furthermore, the patent application details additional steps in the method, such as incubating non-sulfonated DNA with a sulfonation reagent to produce sulfonated DNA, separating the bound DNA from the acidic solution, washing the silica support, desulfonating the DNA, and eluting the desulfonated DNA from the support. The method also includes specific conditions for desulfonation and the removal of the sulfonation reaction solution before combining the sulfonated DNA with the silica support. Additionally, the application describes a composition comprising sulfonated DNA and a silica support in an acidic binding solution with a chaotropic salt, as well as a kit containing bisulfite reagent components, a silica support, and an acidic component for preparing the binding solution, with various characteristics and options for customization.
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