Integra LifeSciences has filed a patent for a tissue graft that aims to improve soft tissue repair or reconstruction. The graft consists of a biopolymer-based matrix with small and large perforations. The small perforations promote clotting and tissue development, while the large perforations allow drainage of fluid and enhance tissue anchoring. The patent claims a specific design with rows of small and large perforations arranged in a square or rectangular pattern. GlobalData’s report on Integra LifeSciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile, Integra LifeSciences's grant share as of September 2023 was 61%. Grant share is based on the ratio of number of grants to total number of patents.

Tissue graft with small and large perforations for soft tissue repair or reconstruction

Source: United States Patent and Trademark Office (USPTO). Credit: Integra LifeSciences Holdings Corp

A recently filed patent (Publication Number: US20230263940A1) describes a tissue graft that has a unique perforation pattern to enhance its functionality and effectiveness in repairing or constructing tissue in a patient. The tissue graft is made of acellular animal tissue and consists of a sheet with both small and large perforations. The small perforations, with a diameter less than 3 mm, are designed to facilitate the formation of fibrin provisional matrix and granulation tissue, which are essential for revascularization and cell repopulation. On the other hand, the large perforations, with a diameter equal to or greater than 3 mm, serve multiple purposes. They allow for the drainage of extravascular tissue fluids, reducing the occurrence of fibrin provisional matrix formation and granulation tissue development within them. Additionally, the large perforations enhance tissue anchoring by providing more contact area for mammal tissue to compress into.

The perforations in the tissue graft are arranged in a specific pattern. The rows of small perforations are parallel to the rows of large perforations, and they alternate with each other. This means that for every four adjacent large perforations, there is one small perforation centered around them, and vice versa. The small and large perforations are distributed in staggered rows and columns, and they are equally spaced throughout the entire surface of the tissue graft. The spacing between adjacent perforations, whether small or large, is about 5 mm to 20 mm.

The patent also includes a method for using the tissue graft in repairing or constructing tissue in a patient. The method involves applying the tissue graft to the patient at an implant site and allowing revascularization and cell repopulation to occur. The tissue graft can be anchored by compressing tissue into the large perforations, increasing the contact area. The method also includes inducing clotting and granulation tissue development within the small perforations, while draining extravascular tissue fluids through the large perforations. Surgical drains or negative pressure wound therapy can be used to remove these fluids from the implant site.

Overall, this patent describes a tissue graft with a unique perforation pattern that aims to enhance its functionality in tissue repair and construction. The specific arrangement and size of the perforations allow for optimal revascularization, tissue anchoring, and drainage of fluids, making it a potentially valuable tool in medical procedures.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies