Pacific Biosciences of California has been granted a patent for labeled nucleotide analogs that enhance fluorescence-based analytical methods, including single molecule real time nucleic acid sequencing reactions. The analogs improve sensitivity, decrease photodamage, and enhance kinetic properties, offering advancements in DNA sequencing technology. GlobalData’s report on Pacific Biosciences of California gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pacific Biosciences of California, Optoelectronic biosensors was a key innovation area identified from patents. Pacific Biosciences of California's grant share as of January 2024 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
Labeled nucleotide analogs for fluorescence-based analytical methods
The granted patent (Publication Number: US11884826B2) discloses a dye-labeled compound of structural formula (IIIG) with specific variations and configurations. The compound includes multiple donor and acceptor dyes, shield elements, side chains, and terminal coupling elements. The side chains may contain components such as polyethylene glycol, sulfonic acid, substituted phenyl groups, triazoles, and more. The compound does not contain a nucleoside and is connected to a nucleotide compound through a terminal coupling element derived from a first reactive functional group.
The patent claims cover various aspects of the dye-labeled compound, including the number and type of dyes, shield elements, side chains, and terminal coupling elements. The compound's structure and components are carefully defined, with specific molecular weights, structures, and configurations outlined in the claims. Additionally, the absence of nucleosides in the compound and the connection to a nucleotide compound through a residue derived from a reactive functional group are highlighted. Overall, the patent provides a detailed description of a novel dye-labeled compound with specific characteristics and functionalities, offering potential applications in various fields such as molecular biology, biochemistry, and diagnostics.
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