Quantum-Si. has filed a patent for methods of sequencing molecules using luminescence lifetimes and intensities. The patent also includes luminescently labeled nucleotides with protecting elements. This innovation could revolutionize nucleic acid sequencing techniques. GlobalData’s report on Quantum-Si gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Quantum-Si, Optoelectronic biosensors was a key innovation area identified from patents. Quantum-Si's grant share as of January 2024 was 18%. Grant share is based on the ratio of number of grants to total number of patents.
Dna sequencing using luminescently labeled nucleotides
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The patent application (Publication Number: US20240035081A1) discloses luminescently labeled nucleotides for use in nucleic acid sequencing. These nucleotides consist of luminescent labels connected to nucleoside polyphosphates via a nucleic acid with a protecting element. The nucleic acid can be single-stranded or double-stranded, with specific configurations involving oligonucleotide strands and linkers. The protecting element includes energy-absorbing modifications such as triplet state quenchers or dendron modifications, as well as unlabeled stem-loops. The invention also encompasses methods for determining the sequence of a template nucleic acid using these luminescently labeled nucleotides, involving exposure to different types of labeled nucleotides, excitation energies, and detection of emitted photons for sequencing.
The luminescently labeled nucleotides described in the patent application offer a novel approach to nucleic acid sequencing, providing enhanced capabilities for identifying nucleotide sequences accurately. By incorporating specific protecting elements and utilizing different configurations of nucleic acids and linkers, the labeled nucleotides can be effectively used in sequencing methods. The method outlined in the patent application involves exposing a complex containing the template nucleic acid to labeled nucleotides, directing excitation energies, detecting emitted photons during nucleotide incorporation, and ultimately determining the sequence based on the emitted photons' timing and frequency. This innovative approach has the potential to advance the field of nucleic acid sequencing by offering a more efficient and accurate method for determining nucleotide sequences.
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