Quest Diagnostics has patented a method for detecting vitamin D metabolites in samples using mass spectrometry. The process involves ionizing the metabolites and analyzing the ions to determine their presence and quantity. The method allows for the detection of multiple metabolites in a single assay. GlobalData’s report on Quest Diagnostics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Quest Diagnostics, was a key innovation area identified from patents. Quest Diagnostics's grant share as of February 2024 was 56%. Grant share is based on the ratio of number of grants to total number of patents.

Method for detecting vitamin d metabolites in samples using mass spectrometry

Source: United States Patent and Trademark Office (USPTO). Credit: Quest Diagnostics Inc

A recently granted patent (Publication Number: US11921122B2) discloses a method for determining the amount of 25-hydroxyvitamin D3 or 25-hydroxyvitamin D2 in a sample using tandem mass spectrometry. The method involves adding an internal standard to the sample, purifying it through liquid chromatography, ionizing the compounds using atmospheric pressure chemical ionization (APCI) in positive ion mode, generating fragment ions, and ultimately determining the amount of the target compounds based on the generated fragment ions.

The patented method also includes additional steps such as utilizing high performance liquid chromatography (HPLC) for the purification process, protein precipitation before liquid chromatography, and specifically mentions that the sample can be plasma or serum. By following these outlined steps, the method allows for accurate quantification of 25-hydroxyvitamin D3 or 25-hydroxyvitamin D2 in a sample, providing a reliable and precise analytical technique for measuring these important biomarkers.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.