Standard BioTools has developed a “looping amplification” method to enhance nucleic acid amplification specificity, enabling advanced multiplexing capabilities. The patented method involves unique primer designs and amplification processes to generate target amplicons with specific structures. GlobalData’s report on Standard BioTools gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Standard BioTools, Microfluidic devices was a key innovation area identified from patents. Standard BioTools's grant share as of February 2024 was 47%. Grant share is based on the ratio of number of grants to total number of patents.
Looping amplification method for nucleic acid specificity increase
A recently granted patent (Publication Number: US11857940B2) discloses a method for amplifying target nucleic acids using specific primers with unique features. The method involves contacting sample nucleic acids with forward and reverse primers, each containing a target-specific portion, a common sequence, a DNA sequencing primer binding site, and a nucleotide tag. The amplification process results in the production of target amplicons with a specific structure, allowing for the formation of stem loop structures. Additionally, the method includes the use of a third primer with a barcode sequence for further identification.
Furthermore, the patent claims cover various aspects of the amplification process, including the amplification of multiple target nucleic acids in a single reaction mixture, the use of a transposon end sequence in the common sequence, and the suppression of amplification cross-hybridization. The method also allows for the amplification of target nucleic acids in microfluidic devices with multiple reaction chambers, enabling high-throughput processing. Additionally, the method can be utilized to produce DNA sequencing libraries and includes the step of sequencing the target amplicons for further analysis. Overall, the patented method offers a novel approach to nucleic acid amplification with unique primer design and structural features that enhance the efficiency and accuracy of the process.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
