Surgalign. has been granted a patent for osteoinductive putties made entirely from donor tissue, specifically demineralized bone matrix. The putties include a carrier of thermally denatured collagen fragments and additional osteogenic or osteoinductive substances, designed for bone defect repair and other medical applications. GlobalData’s report on Surgalign gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Surgalign, Prosthetic cardiac valves was a key innovation area identified from patents. Surgalign's grant share as of July 2024 was 58%. Grant share is based on the ratio of number of grants to total number of patents.
Osteoinductive putty for bone repair using donor tissue
The patent US12059439B2 describes an osteoinductive putty designed for use in bone repair and regeneration. This putty consists of at least three key components: a demineralized bone matrix, a carrier made from thermally denatured collagen fragments, and a further component that includes various osteogenic, osteoinductive, osteoconductive, and medically useful substances. The collagen fragments are derived from the thermal treatment of the demineralized bone matrix, specifically heated at approximately 120°C for about 90 minutes. The putty is characterized by a specific SDS-PAGE profile, indicating the absence of prominent bands in a defined molecular weight range, which differentiates it from standard Type-I collagen.
In addition to its structural components, the putty can incorporate a range of biologically active substances. These include osteogenic substances such as osteoblasts and stem cells, osteoinductive proteins from the TGF-beta superfamily, and bone morphogenetic proteins (BMPs). The putty may also contain osteoconductive materials like allograft or xenograft bone, calcium phosphate, and hydroxyapatite, as well as medically useful substances such as antibiotics and anti-inflammatories. The formulation is designed to remain extrudable after extended storage, making it suitable for practical applications in clinical settings, particularly for packing into bone defects to promote healing and regeneration.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
