3-D Matrix has filed a patent for ionic self-assembling peptides, along with pharmaceutical compositions containing these peptides and methods of using and making them. The patent claims have been canceled. GlobalData’s report on 3-D Matrix gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on 3-D Matrix, cyclosporin derivatives was a key innovation area identified from patents. 3-D Matrix's grant share as of September 2023 was 31%. Grant share is based on the ratio of number of grants to total number of patents.

Ionic self-assembling peptides and their pharmaceutical compositions and methods

Source: United States Patent and Trademark Office (USPTO). Credit: 3-D Matrix Ltd

A recently filed patent (Publication Number: US20230241157A1) describes a method for making a self-assembling peptide. The peptide is composed of the amino acid sequence QLEL12 and can be synthesized and provided in either powder or solution form. The method also allows for the inclusion of functional groups at the N-terminal and C-terminal ends of the peptide, such as acetyl, formyl, biotin, and various other groups. Additionally, the peptide can be modified to include biologically active peptide motifs derived from laminin-1, collagen IV, fibronectin, elastin, bone marrow homing peptides, or myelopeptide.

The patent also covers the use of the self-assembling peptide in the production of pharmaceutical compositions. These compositions can be created by adding the self-assembling peptide to a solution or hydrogel. Tonicity agents, such as salts (e.g., NaCl, KCl) and sugars (e.g., dextrose, mannitol), can be included to adjust the osmotic pressure of the composition. The pH of the composition is typically between 6 and 8, and the net charge of the peptide can be positive or negative. The concentration of the self-assembling peptide in the composition can range from 0.01% to 10% (w/v), depending on the desired application.

The pharmaceutical compositions can also include isolated cells, such as immune cells, stem cells, chondrocyte progenitor cells, and neuronal cells. Additionally, bioactive agents like hormones, growth factors, insulin, enzymes, siRNA, antibodies, and anti-inflammatory agents can be incorporated into the compositions. The compositions can be in the form of aqueous solutions or hydrogels, with the hydrogels having a storage modulus of at least 10 Pascal (Pa). The patent also covers the provision of the pharmaceutical compositions in various articles of manufacture, including syringes, vials, auto-injectors, tubing, and catheters.

Overall, this patent describes a method for making a self-assembling peptide and its use in the production of pharmaceutical compositions. The peptide can be modified with functional groups and biologically active peptide motifs, and the compositions can include tonicity agents, isolated cells, and bioactive agents. The patent provides a range of concentrations, pH values, and forms for the compositions, as well as options for packaging and delivery.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies