Biocept. has filed a patent for pathogen inactivating formulations to collect, transport, and store biological samples while preserving nucleic acids. The claim details a formulation with specific concentrations of detergent, metal chelating agent, and buffer to stabilize RNA in cells. GlobalData’s report on Biocept gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Biocept, Point-of-care molecular diagnostics was a key innovation area identified from patents. Biocept's grant share as of January 2024 was 35%. Grant share is based on the ratio of number of grants to total number of patents.

Formulation for stabilizing rna in biological samples

Source: United States Patent and Trademark Office (USPTO). Credit: Biocept Inc

A recently filed patent (Publication Number: US20240002905A1) describes a formulation designed to lyse cells in a biological sample while stabilizing the RNA contained within them. The formulation consists of a detergent, a metal chelating agent, and a buffer, with specific concentration ranges for each component. When the formulation comes into contact with a biological sample, it can achieve various outcomes such as inactivating nucleases and pathogenic microbes, disrupting protein-nucleic acid associations, and preventing degradation of nucleic acids. The formulation is intended for use with samples derived from subjects, including nasal, oral, saliva, urine, stool, and blood samples, among others.

The patent details the specific components that make up the formulation, including the detergent (such as sodium lauryl sulfate), metal chelating agents (like EDTA and EGTA), and buffers (such as tris(hydroxymethyl)aminomethane). The formulation is designed to maintain a pH range of 6.5 to 7.5 and can be effective in reducing or preventing nucleic acid degradation for extended periods, even at room temperature. Additionally, the patent includes a method for purifying nucleic acids from biological samples using the formulation, highlighting its potential applications in sample collection, transportation, and storage. The formulation aims to provide a reliable and efficient solution for preserving RNA integrity in various biological samples, offering potential benefits for research, diagnostics, and other applications in the field.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies