Glaukos has been granted a patent for a micro-device used in corneal cross-linking treatment. The device includes a body with an outer portion and an inner portion, which forms a chamber over the cornea. An illumination system with micro-light emitting diodes (micro-LEDs) directs photoactivating light to the cornea, generating cross-linking activity with a cross-linking agent. The device also features a spatial light modulator and a controller to produce a pattern of the photoactivating light. The chamber can receive the cross-linking agent to soak the cornea. GlobalData’s report on Glaukos gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Glaukos, Customized implants was a key innovation area identified from patents. Glaukos's grant share as of September 2023 was 41%. Grant share is based on the ratio of number of grants to total number of patents.

Micro-device for corneal cross-linking treatment with illumination system

Source: United States Patent and Trademark Office (USPTO). Credit: Glaukos Corp

A recently granted patent (Publication Number: US11766356B2) describes a micro-device for corneal cross-linking treatment. The device consists of a body with an outer portion and an inner portion. When positioned against the surface of the eye, the outer portion contacts the eye while the inner portion creates a chamber over the cornea. The device includes an illumination system with a micro-optical element that contains multiple micro-light emitting diodes (micro-LEDs). These micro-LEDs direct photoactivating light through the inner portion of the body to the cornea, generating cross-linking activity when a cross-linking agent is applied to the cornea.

The micro-device also features a spatial light modulator with individually addressable pixels that can block or transmit the photoactivating light. A controller is responsible for selectively activating a subset of the micro-LEDs to produce a specific pattern of the photoactivating light. The chamber of the device is designed to receive the cross-linking agent, allowing it to soak the cornea.

The patent also mentions various additional features of the micro-device. The body of the device can be made from an oxygen-permeable material, allowing oxygen to enter the chamber when the device is positioned against the eye. It may also include micro-channels that enable oxygen to enter the chamber. An oxygen delivery mechanism can be coupled to the body to deliver oxygen to the chamber, and the body may have vents to allow oxygen to exit the chamber.

The micro-LEDs in the device are in optical communication with a micro-lens array, which manipulates and focuses the light onto the cornea. The micro-LEDs can be assembled on a flex circuit. The controller can selectively activate the micro-LEDs to produce different patterns of the photoactivating light, including circular or annular shapes. Additionally, the controller can vary the intensity or duration of activation for different micro-LEDs.

Overall, this patent describes a micro-device for corneal cross-linking treatment that utilizes micro-LEDs and a spatial light modulator to deliver photoactivating light to the cornea. The device includes features to ensure oxygen supply to the cornea and allows for customizable patterns of light activation.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.