The Laboratory Corp of America Holdings has filed a patent for methods and systems to isolate and detect microbes from samples using binding agents. The invention includes ribosome-based and bacteriophage-based amplification for detecting bacteria and achieving significant signal amplification. GlobalData’s report on Laboratory Corp of America Holdings gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Laboratory Corp of America Holdings, Molecular diagnosis biomarkers was a key innovation area identified from patents. Laboratory Corp of America Holdings's grant share as of January 2024 was 44%. Grant share is based on the ratio of number of grants to total number of patents.

Microbe detection method using ribosome-based amplification

Source: United States Patent and Trademark Office (USPTO). Credit: Laboratory Corp of America Holdings

The patent application (Publication Number: US20240027445A1) describes a method for detecting a microorganism of interest by isolating the microorganism from a sample, lysing it to release ribosomes, and detecting these ribosomes or their constituents. The method involves binding the microorganism to a binding agent, such as an antibody specific to the microorganism, and using primary and secondary antibodies for ribosome detection. Additionally, the patent covers a method specifically for detecting a bacterium of interest by infecting it with bacteriophages, lysing the infected bacterium to release progeny bacteriophages, and detecting these progeny bacteriophages or their constituents.

Furthermore, the patent application includes kits for detecting microorganisms of interest, comprising components for isolating the microorganism, lysing it to release ribosomes, and detecting these ribosomes or their constituents. Another kit is designed for detecting microorganisms by infecting them with infectious agents, lysing the infected microorganisms to release progeny infectious agents, and detecting these progeny agents or their constituents. These methods and kits provide a comprehensive approach to detecting specific microorganisms, such as bacteria, fungi, or yeast, by leveraging ribosome detection and bacteriophage infection techniques.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies