OraSure Technologies. has been granted a patent for a method that preserves cells and extracellular components in bodily fluids like saliva for medical diagnosis. The technique involves a preservation solution to stabilize samples for analyzing cancer and other conditions, enhancing diagnostic capabilities. GlobalData’s report on OraSure Technologies gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on OraSure Technologies, Biological sampling devices was a key innovation area identified from patents. OraSure Technologies's grant share as of June 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.
Cell preservation and analysis for medical diagnosis
The granted patent US12038434B2 outlines a method for diagnosing and monitoring cancer using saliva samples from subjects. The process begins with the collection of a saliva sample, which is then stabilized by mixing it with a preservation solution. This solution contains paraformaldehyde, serum proteins (such as fetal bovine serum), and sodium azide, and is buffered to a pH between 6.4 and 8.4. After storing the mixture at room temperature, the method involves separating extracellular components—proteins, free-floating DNA, and free-floating RNA—from the cells. The final step includes analyzing these components through various molecular techniques, including sequencing, to diagnose or monitor cancer, specifically targeting types such as lung cancer and leukemia.
Additionally, the patent describes methods that not only diagnose and monitor cancer but also determine and administer drug treatments based on the analysis of the saliva sample. The preservation solution's specific composition and the analytical techniques employed, such as whole genome sequencing and RNA sequencing, are critical to the method's effectiveness. The claims emphasize the importance of using a 1:1 volume ratio of saliva to preservation solution and highlight the potential for analyzing multiple analytes to enhance diagnostic accuracy. Overall, this patent presents a novel approach to cancer diagnostics that leverages non-invasive saliva sampling and advanced molecular analysis techniques.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
