T2 Biosystems has been granted a patent for containers designed for holding liquid samples and lysing cells. The containers have a unique design with linear protrusions and can be used for mixing and lysing cells in liquid samples. The patent also covers the method of using these containers to agitate the liquid with sufficient force and duration to lyse the cells. GlobalData’s report on T2 Biosystems gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on T2 Biosystems, MRI calibration techniques was a key innovation area identified from patents. T2 Biosystems's grant share as of June 2023 was 1%. Grant share is based on the ratio of number of grants to total number of patents.
Patent granted for containers and methods for lysing cells
A recently granted patent (Publication Number: US11666872B2) describes a method for lysing cells in a liquid sample. The method involves providing a container with an interior chamber that has a substantially circular or polygonal cross-section. The surface of the interior chamber contains one or more substantially linear protrusions parallel to the central axis. The liquid sample in the container includes both rigid particles and cells. The method further includes agitating the liquid in the container with sufficient force and duration to lyse the cells.
The patent also discloses a method for detecting the presence of a target nucleic acid in a whole blood sample. This method involves producing an extract by lysing the red blood cells in the sample, centrifuging the sample to form a supernatant and a pellet, discarding some or all of the supernatant, and resuspending the pellet to form an extract. The extract contains additional cells. The additional cells in the extract are lysed by combining the extract with rigid particles in a container with an interior chamber that has a substantially circular or polygonal cross-section and contains one or more substantially linear protrusions parallel to the central axis. The mixture is agitated with sufficient force and duration to lyse the additional cells, forming a lysate. The lysate is then subjected to nucleic acid amplification in a detection tube to form an amplified lysate solution. The amplified solution contains the target nucleic acid and non-target nucleic acid.
Overall, this patent describes methods for lysing cells in a liquid sample and detecting target nucleic acids in whole blood samples. The use of containers with interior chambers containing linear protrusions parallel to the central axis allows for efficient cell lysis. These methods have potential applications in various fields, including medical diagnostics and research.