Abbott has announced that data from a new study has shown that two blood-based biomarkers measured using its tests were able to predict a patient’s recovery from traumatic brain injury (TBI).
The company stated that testing for these two biomarkers immediately after an injury can help doctors determine the best treatments and care for patients.
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In the study, published in The Lancet Neurology, Abbott’s i-STAT TBI Plasma test and its ARCHITECT core laboratory instrument were used to measure the two biomarkers in a blood sample.
It demonstrated that clinicians could get a more precise picture of the injury, the expected course of recovery and the long-term effects of the TBI by performing the blood test soon after an injury.
The researchers evaluated the glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) levels in the blood plasma within 24 hours of an injury.
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After evaluating the biomarker levels on the day of the injury, they assessed patients for six months.
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By GlobalDataThe researchers kept track of biomarker levels as well as how patients fared during their recovery.
University of Michigan emergency medicine associate professor Dr Fred Korley said: “Brain injury biomarkers will one day be the standard of care to evaluate and treat patients.
“Objective biomarker data can be profoundly helpful in determining prognosis for a patient, helping to gauge how severe a brain injury is, and can ultimately inform how best to counsel family members about care for their loved ones with brain injury.”
The researchers compared 1,696 TBI patients’ day-of-injury blood tests with their six-month assessment using the Glasgow Outcome Scale Extended, which rates the outcomes and quantifies the disability levels after TBI.
They discovered that high biomarker values for UCH-L1 and GFAP correlated with death and serious injury.
The day-of-injury blood tests showed a high chance of predicting death at six months, with 87% for GFAP and 89% for UCH-L1, as well as a high likelihood of predicting serious disability, with 86% for GFAP and UCH-L1.
In June, Abbott received US Food and Drug Administration (FDA) approval for its next-generation FreeStyle Libre 3 system for use by diabetic patients.
