Bio-Techne has entered a strategic partnership with Lunaphore for the development of a fully automated spatial multiomics solution.

Under the partnership, the companies will engage in the development of the first fully automated spatial multiomics workflow for same-slide hyperplex detection of protein and RNA biomarkers.

The new solution is expected to offer ultimate flexibility in panel design. It will also help researchers to easily incorporate antibodies with RNAscope in situ hybridisation probes to highlight changes in cell phenotypes and functional states across different diseases.

Bio-Techne’s diagnostics and genomics segment president Kim Kelderman said: “Multiomics spatial imaging has the potential to transform our understanding of disease and accelerate the development of novel therapeutics and next-generation diagnostics.”

Lunaphore’s multiplex sequential immunofluorescence (seqIF) solution portfolio will be leveraged by the multiomics solution to offer tissue morphology, scalability and reproducibility.

The seqIF portfolio includes the SPYRE antibody panels and the COMET instrument.

COMET can be easily integrated within the standard histology workflow to facilitate the detection of hyperplex protein at single-cell and subcellular resolution. It leverages the existing libraries of non-conjugated primary antibodies.

Furthermore, the automated workflow will use RNAscope HiPlex technology to visualise RNA biomarkers with single-molecule sensitivity and specificity.

Lunaphore CEO Ata Tuna Ciftlik said: “The addition of RNAscope HiPlex capability into our recently announced COMET product suite will help researchers to truly streamline and automate spatial proteomic, transcriptomic and multiomics assay workflows with push-button automation, eliminating existing manual upfront steps on all three modalities.”