The Synergy Bioabsorbable Polymer Stent System. Credit: Boston Scientific Corporation.

Boston Scientific has announced positive data from the EVOLVE Short DAPT clinical trial of its Synergy Bioabsorbable Polymer (BP) Stent in patients at high bleeding risk after percutaneous coronary intervention.

The trial aimed to determine the safety of a shortened dual antiplatelet therapy (DAPT) duration following treatment with the Synergy stent. Results showed that a three-month DAPT regimen is non-inferior to a 12-month or longer regimen.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

EVOLVE Short DAPT trial involved a total of 2,009 subjects, including 1,487 patients eligible to stop DAPT at three months. Participants received an implant of at least one Synergy stent.

The co-primary endpoints of the trial were the rate of death or myocardial infarction (MI) and the rate of stent thrombosis between three and 15 months. The company noted that both endpoints were met.

According to findings, the rate of death or MI between three and 15 months was non-inferior in patients who received the three-month DAPT versus those on 12-month DAPT.

The rate of stent thrombosis between three and 15 months was 0.3% in the three-month DAPT group, which is said to be considerably lower compared to the endpoint performance goal of 1%.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Boston Scientific executive vice-president and global chief medical officer Ian Meredith said: “We are pleased the study presented today provided robust safety data on shortened DAPT following implantation of the Synergy BP Stent for this patient population, as the reduced length of therapy can be a clinically significant differentiator.

“We continue to build upon the body of evidence supporting the excellent clinical outcomes of the Synergy BP Stent and look forward to submitting these data to regulatory authorities to support an indication for use of this stent in patients at high risk of experiencing a bleeding event.”

Earlier this month, the Synergy Megatron BP Stent received the European CE-Mark.