A new study by an international research team has revealed the potential role of the chemicals released by gut microbes as indicators of early stages of non-alcoholic fatty liver disease (NAFLD) and the possibility for a simple blood test to detect them.

The team was led by researchers from Imperial College London, UK; University of Girona, Spain; University of Rome Tor Vergata, Italy; and INSERM in Toulouse, France.

“It was observed that increased levels of the phenylacetic acid compound produced by gut bacteria were linked to the accumulation of fat in the liver.”

Conducted to understand the link between NAFLD and the microbiome, the study resulted in the identification of the phenylacetic acid (PAA) compound produced by gut bacteria. This compound was found to be associated with the early onset of the liver disease.

Imperial College London Surgery & Cancer department researcher Dr Lesley Hoyles said: “Through this work we may have uncovered a biomarker for the disease itself. Overall, it demonstrates the microbiome is definitely having an effect on our health.”

During the study, biological data such as blood, urine, liver biopsy and faecal samples from 100 obese women with fatty livers was compared with that of healthy patients.

It was observed that increased levels of PAA were linked to the accumulation of fat in the liver. This observation was validated in animal testing.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The researchers further discovered a connection between the liver disease and subtle changes in the genetic makeup of the microbiome. The number of genes encoded by gut bacteria decreased with the progression of the disease.

Based on the results, the team concluded that PAA can potentially act as a biological marker in the clinic, where blood samples can be analysed for the compound in order to detect an increased risk of the disease.

However, further studies are required to confirm the role of the gut microbiome as a diagnostic indicator of fatty liver disease.