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July 13, 2020

Inscopix to collaborate with Bruker for MIRA platform

Inscopix and Bruker have announced a collaboration for the former’s new multimodal image registration and analysis (MIRA) platform.

Inscopix and Bruker have announced a collaboration for the former’s new multimodal image registration and analysis (MIRA) platform.

As part of the collaboration, the company will combine its miniature microscope-based nVista and nVoke systems with Bruker’s Ultima multiphoton microscopes.

It will enable brain researchers to catalyse a comprehensive mechanistic understanding of the brain by integrating one-photon imaging of neuronal activity with high-resolution multi-colour imaging of diverse cell-types and pathologies in the brain.

The combined solution, which will be co-marketed by the companies, includes an adapter to integrate Inscopix miniscope data from freely-moving animals with multi-colour laser scanning microscope data from head-fixed animals.

It also features an Inscopix-developed software solution to streamline co-registering of images received from both modalities.

Inscopix founder and CEO Kunal Ghosh said: “We are very excited to announce the launch of the MIRA platform and the collaboration with Bruker, a leader in multiphoton imaging-based applications for neuroscience.

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“This partnership with Bruker is a key part of our strategy to work with partners in the neuroscience imaging industry to help researchers record, align, register and correlate changes in neural activity in a defined population of neurons with changes in other brain cell-types and pathologies.”

Using MIRA platform, researchers can first image large-scale brain activity at single-cell resolution in freely-behaving animal subjects.

They can also image the same field-of-view in the brain with multiphoton and confocal microscopes at higher resolution and at multiple wavelengths.

Bruker Fluorescence Microscopy Business vice-president and general manager Xiaomei Li said: “Inscopix’s MIRA platform is an important innovation that will, when used in conjunction with our Ultima multiphoton microscopy, combine the many advantages of one-photon and multiphoton imaging while overcoming previous technological limitations for a richer and more sophisticated understanding of the brain.”

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