Inscopix to collaborate with Bruker for MIRA platform
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Inscopix to collaborate with Bruker for MIRA platform

13 Jul 2020 (Last Updated July 13th, 2020 11:48)

Inscopix and Bruker have announced a collaboration for the former’s new multimodal image registration and analysis (MIRA) platform.

Inscopix to collaborate with Bruker for MIRA platform
MIRA platform has been designed to enable researchers to image large-scale brain activity at single-cell resolution in freely-behaving animal subjects. Credit: Sanger Brown MD.

Inscopix and Bruker have announced a collaboration for the former’s new multimodal image registration and analysis (MIRA) platform.

As part of the collaboration, the company will combine its miniature microscope-based nVista and nVoke systems with Bruker’s Ultima multiphoton microscopes.

It will enable brain researchers to catalyse a comprehensive mechanistic understanding of the brain by integrating one-photon imaging of neuronal activity with high-resolution multi-colour imaging of diverse cell-types and pathologies in the brain.

The combined solution, which will be co-marketed by the companies, includes an adapter to integrate Inscopix miniscope data from freely-moving animals with multi-colour laser scanning microscope data from head-fixed animals.

It also features an Inscopix-developed software solution to streamline co-registering of images received from both modalities.

Inscopix founder and CEO Kunal Ghosh said: “We are very excited to announce the launch of the MIRA platform and the collaboration with Bruker, a leader in multiphoton imaging-based applications for neuroscience.

“This partnership with Bruker is a key part of our strategy to work with partners in the neuroscience imaging industry to help researchers record, align, register and correlate changes in neural activity in a defined population of neurons with changes in other brain cell-types and pathologies.”

Using MIRA platform, researchers can first image large-scale brain activity at single-cell resolution in freely-behaving animal subjects.

They can also image the same field-of-view in the brain with multiphoton and confocal microscopes at higher resolution and at multiple wavelengths.

Bruker Fluorescence Microscopy Business vice-president and general manager Xiaomei Li said: “Inscopix’s MIRA platform is an important innovation that will, when used in conjunction with our Ultima multiphoton microscopy, combine the many advantages of one-photon and multiphoton imaging while overcoming previous technological limitations for a richer and more sophisticated understanding of the brain.”