Researchers from the Hong Kong Polytechnic University (PolyU) have created a self-fitting scaffold that can be implanted into bone defects to stimulate bone regeneration.

The new scaffold comprises shape memory polyurethane foam along with the bone tissue component hydroxyapatite. It is intended to improve the recovery of bone injuries and fractures.

Due to the use of shape memory material, the scaffold can be compacted at 0°C and implanted with this shape at room temperature. It can also recover to its original shape at 40°C.

“The new scaffold comprises shape memory polyurethane foam along with hydroxyapatite. It is intended to improve the recovery of bone injuries and fractures.”

This capability enables scaffold to fill up the irregular bone defects, while the transitional temperatures increase its feasibility in minimally invasive surgical procedures.

The bone scaffold has a highly porous, interconnected structure that enables cells to migrate and form new tissues.

The average pore size of the scaffold is 670μm, which is said to be mostly similar to that of the inner layer of bone, allowing duplication of the original in-vivo microenvironment. Its optimal structure is nearly 60% of space voids.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

When tested in the laboratory, the self-fitting scaffold was found to be biocompatible without any cytotoxicity.

In an animal study, a total of 18 rabbits having femoral bone defects were implanted with the new scaffolds compacted to about 50% of their actual size.

Upon triggering with 40°C saline, the scaffolds were observed to have expanded from their compacted shape to fill the defect in 60 seconds.

A faster bone tissue ingrowth in volume was found after 12 weeks from the surgery. The implanted rabbits showed 46% of bone ingrowth when compared to 24% in the control group.

The self-fitting scaffold also demonstrated the capability to induce the formation of the osteoblasts and blood vessels.

PolyU researcher Hu Jinlian said: “The results show that our scaffold has overcome the disadvantages of traditional polymer scaffolds, and has great potential for bone regeneration.”