Swiss global healthcare firm Roche has expanded its Ventana modular-based detection kits with the launch of the new Discovery Yellow Kit in order to carry out cancer research.

The kits will support in the identification and profiling of cancer biomarkers and tumour cell populations.

Discovery Yellow is an alkaline phosphatase-based detection chemistry for tissue diagnostics, which produces a transparent yellow signal that cannot be washed during alcohol dehydration, such as some precipitating dyes, and fits into routine laboratory workflow.

“Our beta test customers are very impressed with the strong, distinct, crisp and transparent staining quality by Discovery Yellow.”

The new detection kit advances research with the Discovery Ultra, a fully automated immunohistochemistry (IHC) and in situ hybridisation (ISH) staining platform.

Roche tissue diagnostics head Ann Costello said: "By providing additional staining detection flexibility to the research community, we give our customers more options in their multiplexing applications, allowing for further advancement in their biomarker research.

"Our beta test customers are very impressed with the strong, distinct, crisp and transparent staining quality by Discovery Yellow on different types of tissue."

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The new kit is available in ready-to-use dispensers that can be fully automated on the Discovery Ultra system, providing researchers with enhanced productivity for increasingly complex assay requirements.

It can also be used in combination with other dyes to offer a colour that contrasts with other chromogens.

The company’s other modular chromogens include Discovery Purple, Discovery Red and Discovery Silver, which will allow users to select multiple markers for multiplexing. These can be simultaneously studied with limited tissue samples.

Discovery Yellow can be used in conjunction with other chromogens to detect signal co-localisation, in which the spatial overlapping of two signals can be studied by forming a third colour.

Image: Confirm Ki67 with ChromoMap DAB Detection Kit + Cytokeratin 19 with Discovery Yellow Detection Kit + E-cadherin with Discovery Purple Detection Kit in lung. Photo: courtesy of PRNewsFoto/Roche.