View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
May 25, 2022

Pancryos enters licence agreement for macroencapsulation device

The device was shown to boost survival and insulin secretion of cells in preclinical models.

Pancryos has entered a worldwide exclusive licence agreement with Brigham and Women’s Hospital for the convection-enhanced macroencapsulation device (ceMED).

A team of researchers from Brigham and Women’s Hospital, Harvard Stem Cell Institute (HSCI), Harvard University and the University of Massachusetts Medical School developed ceMED.

This device will act as the delivery mechanism for the company’s stem cell-derived, natural insulin production therapy, PanINSULA, for the treatment of type 1 diabetes.

It is intended to enhance cell loading capacity while boosting the survival of the cell, glucose sensitivity and timely secretion of insulin. 

The device was shown to boost survival and insulin secretion of cells in preclinical models and started to reduce blood glucose levels as early as two days after transplantation. 

When compared to current diffusion-based devices, ceMED offers substantial advantages, including better cell survival, decreased fibrous encapsulation, and faster on and off rates for insulin secretion.

According to initial findings obtained with the ceMED device, its distinctive design may be able to overcome the mass transport limitations of standard macroencapsulation devices and could also facilitate the delivery of greater doses to cells without affecting their viability or function.

Pancryos co-founder Henrik Semb said: “Our goal is to offer all patients with type 1 diabetes a safe and sustainable source of enriched immune-protected functional stem cell-derived beta cells. 

“This exclusive licence puts Pancryos in a unique position to deliver our high-quality beta cells with the innovative ceMED device that will protect the cells from immune attack. 

“This is a very exciting development for the treatment of Type 1 Diabetes and the millions who suffer without a cure.”

Impacting more than 50 million people globally, type 1 diabetes has no known treatment.

Related Companies

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. The top stories of the day delivered to you every weekday. A weekly roundup of the latest news and analysis, sent every Friday. The medical device industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Medical Device Network