The trial aims to improve treatment options for severe COPD/emphysema patients with the Zephyr valve. Credit: kalhh from Pixabay.

Pulmonx, a provider of minimally invasive treatments for COPD, has treated the first subject in the CONVERT II pivotal trial with the AeriSeal system.

This international study is evaluating the AeriSeal system’s ability to limit collateral ventilation in severe COPD/emphysema patients, potentially increasing the number of patients who can benefit from Zephyr valves, a minimally invasive treatment option.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

The AeriSeal System is engineered to occlude openings in the lung fissures that cause collateral ventilation, which can prevent effective treatment with Zephyr valves.

The trial follows staged investigational device exemption approval by the US Food and Drug Administration and aims to establish the safety and efficacy of the AeriSeal System in treating fissural defects.

Patients with confirmed collateral ventilation using Pulmonx’s Chartis Pulmonary Assessment System are eligible for the AeriSeal System treatment.

See Also:

If the treatment converts the patient’s lungs to a state suitable for valve implantation, they will receive Zephyr valves as per the current standard of care.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The trial’s success metrics include lung volume reduction and improvements in lung function, quality of life and exercise capacity, assessed six months post-treatment.

Pulmonx president and CEO Glen French said: “We hope the CONVERT II Trial will move us closer to the goal of helping patients with collateral ventilation to also receive benefit from our Zephyr valves.”

The CONVERT II Pivotal Trial will enrol nearly 200 patients across up to 30 sites in the US, Australia and Europe.

The six-month post-treatment results will support a pre-market approval application, building on the positive outcomes from the earlier CONVERT Trial.

University Hospital in Brescia, Italy, ASST Spedali Civili interventional pulmonology director Dr Michela Bezzi said: “We know Zephyr valves can provide durable improvements in lung function, breathing and quality of life, but for patients with incomplete fissures the treatment does not work effectively.

“Having a technology to seal openings in fissures means we can improve the lives of many more patients using minimally invasive procedures.”