Roche launches genomic profiling kit to aid cancer research
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Roche launches genomic profiling kit to aid cancer research

26 Oct 2021 (Last Updated October 26th, 2021 12:48)

Roche jointly developed the new AVENIO Tumor Tissue CGP Kit with Foundation Medicine.

Roche launches genomic profiling kit to aid cancer research
The Roche Tower, headquarters of Roche, in Basel, Switzerland. Credit: Taxiarchos228 / commons.wikimedia.org.

Roche has launched a new genomic profiling kit to help laboratories strengthen their in-house cancer research.

The new AVENIO Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit is a research use only sequencing assay developed to offer an end-to-end workflow from DNA extraction and library preparation to generation of variant results.

It is developed by Roche, in collaboration with its unit Foundation Medicine, to further bolster its CGP portfolio.

Researchers can use the AVENIO Tumor Tissue CGP Kit with Foundation Medicine’s comprehensive genomic profiling for oncology research in their own laboratories. This eliminates the need to send tissue samples to centralised laboratories.

The kit will also provide information on complex genomic signatures such as tumour mutational burden (TMB), microsatellite instability (MSI) and loss of heterozygosity (LOH).

According to Roche, a future version of the kit may provide clinicians with additional resources for the diagnosis and treatment of cancer.

Roche Diagnostics CEO Thomas Schinecker said: “To treat cancer effectively, we must understand what drives it at a molecular level. CGP helps inform decisions about available treatment options, including targeted therapies, immunotherapies, tumour-agnostic treatments and clinical trial participation, based on the unique genomic profile of a patient’s tumour.

“We are bringing powerful insights from CGP to enable smarter, more efficient research and development. Our new kit provides the information researchers need and will ultimately provide insights physicians can use to develop personalised treatment strategies for individual patients.”

The AVENIO Tumor Tissue CGP Kit leverages a gene panel based on the FoundationOne platform designed to match the FoundationOne CDx panel content to assess 324 cancer-related genes across four main classes of genomic alterations and signatures.

Each of the kits can run 24 samples.

Earlier this month, the US Food and Drug Administration (FDA) approved the Roche VENTANA PD-L1 (SP263) Assay as a companion test for lung cancer.