Stanford researchers develop needle-free HIV test

23 January 2018 (Last Updated January 23rd, 2018 10:29)

Researchers from Stanford University in the US have partnered with the Alameda County Public Health Laboratory to develop a simple, ‘hassle-free’ diagnostic test for HIV.

Stanford researchers develop needle-free HIV test
Researchers working on an earlier version of their test in 2016. Credit: LA Cicero.

Researchers from Stanford University in the US have partnered with the Alameda County Public Health Laboratory to develop a simple, ‘hassle-free’ diagnostic test for HIV.

The research is aimed at addressing the concerns with existing blood tests that are reliable and detect infections early but have few volunteers, or saliva test that is considered less reliable during the initial stages of infection.

A blood sample is said to contain numerous antibodies that are formed by the body’s immune system to fight against the HIV infection, while saliva is reported to lack the amount required for early detection.

In the new test, the researchers combined the reliability of blood with the convenience of saliva tests to ensure detection before the infection could spread.

Stanford University chemistry professor Carolyn Bertozzi said: “The earlier you can detect, the better, because people can infect other people.

“Every day that goes by that a person’s behaviour is not modified based on their HIV status is a day that they could be infecting other people, especially for young people.”

“The test was also able to avoid false positives in the remaining 22 HIV-negative participants.”

For the new test, bits of HIV were attached to one or the other arm of a DNA piece that was added into the saliva sample, where the arms would bind to the HIV antibodies, allowing easy identification using conventional laboratory methods.

While additional studies are required, the test is reported to have demonstrated the ability to correctly detect 22 subjects who tested HIV-positive using other methods.

The test was also able to avoid false positives in the remaining 22 HIV-negative participants.

Bertozzi added: “Our hope is that we can get an earlier read than the present oral test because the sensitivity is better.”