ClearNote Health has announced that its Avantect test could detect pancreatic cancer in high-risk patients, such as those diagnosed with Type 2 diabetes recently, in a study.
The company revealed the data from the study ‘Epigenomic Blood-based Early Detection of Pancreatic Cancer Employing Cell-free DNA.’
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The Avantect Pancreatic Cancer Test primarily assesses alterations in 5-hydroxymethylcytosine (5hmC) signals in cell-free DNA obtained from plasma.
According to the company, the study is designed to describe the DNA-based blood test’s development and validation.
The case-control validation study, which involved 2,150 patient samples, indicated high specificity of 96.9% and early-stage (Stage I/II) sensitivity of 68.3%.
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ClearNote Health chief scientific officer Samuel Levy said: “Our unique approach to early detection combines epigenomics with genomic alterations and fragmentomics as input to sophisticated machine learning algorithms.
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By GlobalData“This enables us to offer clinicians an early detection test that can be used to guide patient management recommendations and identify pancreatic cancers at early, treatable stages when longer-term patient survival is still possible.”
The test is supported by the company’s automated, 5hmC-based epigenomic platform, which measures active biological events that take place in tumours during the early stages of cancer formation.
This platform enhances DNA fragments through 5hmC labelling to target a subset of dynamically demethylated bases.
Furthermore, the new data confirm that the company’s epigenomic platform is useful for detecting cancer in individuals who are at a higher risk of developing pancreatic cancer. It enables timely detection and intervention of the disease.
