The new electroporation system enables gene modifications without using traditional viral vectors.
Using the Gibco CTS Xenon Electroporation System cell therapy, developers will have complete control of optimising various hard-to-transfect cell types and payloads.
Featuring programmable, flexible electroporation conditions, the device can be used as a standalone technology or integrated with the Gibco CTS Rotea Counterflow Centrifugation System as part of an automated cell therapy manufacturing workflow.
Thermo Fisher Scientific biosciences president Amy Butler said: “We launched the CTS Rotea System in 2020 as part of our strategy to deliver fit-for-purpose cell therapy solutions that can easily scale from development to commercialisation.
“Adding the CTS Xenon Electroporation System to our end-to-end workflow will help customers overcome manufacturing challenges that hinder production, enabling them to bring life-saving therapies to patients faster.”
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The Xenon Electroporation System offers transfection performance in volumes of up to 2.5e9 cells in 25 mL in a sterile system. This enables quick non-viral transfection for clinical manufacturing applications.
Additionally, the CTS solution provides 90% gene knockout transfection and up to 80% cell viability, which supports scaling from the small-volume Neon Transfection System without the need to re-optimise electroporation parameters.
The CTS product line from Thermo Fisher is designed to work across the complete workflow, from cell isolation/activation to cell engineering and expansion, in order to address the manufacturing needs of cell therapy developers.
Recently, Thermo Fisher launched two new reverse transcription loop-mediated isothermal amplification-based solutions for simplifying surveillance of viral pathogens, including SARS-CoV-2.