View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
July 4, 2022

University of Tokyo develops compact patch to detect SARS-CoV-2 virus

The researchers developed microneedles made of polylactic acid to draw ISF from the skin.

Researchers from the Institute of Industrial Science at the University of Tokyo, Japan, have developed a new antibody-based compact skin patch that can quickly detect the presence of SARS-CoV-2 virus without needing a blood sample.

The predominant Covid-19 detection method currently in use involves the collection of swab samples from the nose and throat.

This process is restricted by its high cost, long detection time, and requirement for specialised equipment and medical personnel, especially in countries where resources are limited.

An alternative method for Covid-19 detection is testing strips developed using gold nanoparticles that require blood samples collected through a finger prick with a lancet and provide results in ten to 20 minutes.

These tests are currently used for point-of-care testing to detect SARS-CoV-2-specific antibodies in many countries.

The Japanese researchers explored the sampling and testing of the interstitial fluid (ISF) in the epidermis and dermis layers of human skin to develop a minimally invasive detection test.

Institute of Industrial Science, University of Tokyo lead author Leilei Bao said: “Although the antibody levels in the ISF are approximately 15% to 25% of those in blood, it was still feasible that anti-SARS-CoV-2 IgM/IgG antibodies could be detected and that ISF could act as a direct substitute for blood sampling.”

Initially, the researchers developed biodegradable porous microneedles, made of polylactic acid, to draw ISF from the skin.

A paper-based immunoassay biosensor was later developed to detect the SARS-CoV-2-specific antibodies in the ISF.

By integrating the microneedles and biosensor, the researchers have created the compact patch system, which can detect antibodies within three minutes.

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. The top stories of the day delivered to you every weekday. A weekly roundup of the latest news and analysis, sent every Friday. The medical device industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy


Thank you for subscribing to Medical Device Network