View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
November 18, 2021

University of Missouri method can detect false-positive Covid-19 tests

The quality control procedure detects false-positive Covid-19 results to prevent unnecessary quarantine and repeated testing.

Scientists at the University of Missouri School of Medicine in the US have developed a procedure to detect potential false-positive Covid-19 test results.

Free Report
img

Build resilience in the face of COVID-19 disruption

COVID-19 has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities. Are you interested in actionable insights on the business challenges induced by the pandemic? GlobalData's cross-sector report analyzes the significance of this major disruptive theme across industry verticals. It provides side-by-side research of alternative datasets to present you with unique quantitative analysis of the effects of COVID-19 and how these differ across sectors. Additionally, it offers qualitative analysis of each sector and analyzes COVID-19’s impact on leading companies. Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today.
by GlobalData
Enter your details here to receive your free Report.

The new process is expected to help laboratories avoid unnecessary quarantining and repeated testing of non-infected people.

The university scientists have developed a quality control procedure for detecting false-positive Covid-19 results from the reverse transcriptase-polymerase chain reaction (RT-PCR) test.

This test is considered reliable and has been the most widely used method for virus testing during the Covid-19 pandemic.

However, a small number of false-positive results have been delivered by the test, often found in asymptomatic and nonexposed patients.

University of Missouri School of Medicine pathology and anatomical sciences professor and molecular diagnostics laboratory director Lester Layfield said: “False-positive diagnoses have important implications for patient management.

“False positives may lead to inappropriate quarantine, delay of other necessary medical treatment or transfer to a Covid-19 ward.”

Layfield and his research team started repeat testing of all SARS-CoV-2 positive results from asymptomatic and unexposed patients to ensure the accuracy of positive tests.

By implementing the quality control protocol, they have retested all specimens from asymptomatic or unexposed persons with SARS-CoV-2 positive test results which were stored next to a specimen with a high viral load.

Last September, the researchers’ team implemented the quality control protocol on 24,717 RT-PCR tests over an eight-week period.

Of the total, 6,251 of the RT-PCR tests were from asymptomatic patients. 288 of these specimens delivered positive results.

During the second test, 20 of the specimens were false positives.

Layfield added: “Retesting of positive results from asymptomatic individuals revealed some technologist errors but also contamination from positive specimens in adjacent specimen wells.

“This study should alert the laboratory testing community of the possibility of false-positive Covid-19 tests.”

Related Companies

Free Report
img

Build resilience in the face of COVID-19 disruption

COVID-19 has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities. Are you interested in actionable insights on the business challenges induced by the pandemic? GlobalData's cross-sector report analyzes the significance of this major disruptive theme across industry verticals. It provides side-by-side research of alternative datasets to present you with unique quantitative analysis of the effects of COVID-19 and how these differ across sectors. Additionally, it offers qualitative analysis of each sector and analyzes COVID-19’s impact on leading companies. Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today.
by GlobalData
Enter your details here to receive your free Report.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. The top stories of the day delivered to you every weekday. A weekly roundup of the latest news and analysis, sent every Friday. The medical device industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Medical Device Network