Thermo Fisher Scientific. has been granted a patent for new cationic lipids designed to facilitate the delivery of macromolecules, including nucleic acids, into eukaryotic cells. These lipids can be utilized independently or in conjunction with other lipids and transfection enhancers to create effective transfection complexes. GlobalData’s report on Thermo Fisher Scientific gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Thermo Fisher Scientific, Nanoemulsion cosmetics was a key innovation area identified from patents. Thermo Fisher Scientific's grant share as of June 2024 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
Cationic lipids for delivering nucleic acids into cells
The granted patent US12043639B2 outlines a series of claims related to a novel compound represented by Formula I, which is designed for use in various biological applications. The claims specify the structural components of the compound, including variations of the substituent Y, which can be selected from a range of alkyl groups such as methyl, ethyl, and isopropyl. Additionally, the claims detail compositions that incorporate the compound of Formula I alongside various lipids, transfection agents, fusion agents, and cell surface ligands, potentially enhancing the compound's efficacy in cellular applications. Notably, the compositions may also include nucleic acids, such as DNA and RNA, with specific mention of RNA interference (RNAi) molecules.
Furthermore, the patent describes methods for introducing nucleic acids, proteins, or peptides into eukaryotic cells using the claimed compositions. These methods are applicable to human and animal cells, facilitating the expression or inhibition of specific proteins. The claims also highlight the inclusion of polycationic nucleic acid binding moieties, which can enhance the binding and delivery of nucleic acids within cells. Examples of these moieties include polyethyleneimine (PEI) and various polybasic peptides, such as poly-lysine and poly-arginine. Overall, the patent presents a comprehensive framework for utilizing the compound and its associated compositions in genetic and protein delivery systems.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
