BioNano Genomics. has filed a patent for cell lysis buffers containing a buffering agent, detergent, and cyanate or thiocyanate. The composition, free of urea and carbonic acid, can effectively lyse cells in tissues and is suitable for isotachophoresis. The claim specifies the relative concentration ratios of components. GlobalData’s report on BioNano Genomics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on BioNano Genomics, Microfluidic devices was a key innovation area identified from patents. BioNano Genomics's grant share as of January 2024 was 33%. Grant share is based on the ratio of number of grants to total number of patents.

Cell lysis buffers with cyanate or thiocyanate

Source: United States Patent and Trademark Office (USPTO). Credit: BioNano Genomics Inc

The patent application (Publication Number: US20230416724A1) discloses a composition comprising a buffer in aqueous solution, a detergent, and a specific concentration range of cyanate or thiocyanate. The relative concentration of cyanate or thiocyanate to urea in the composition is specified to be at least 1:800, with variations up to 1:1,000,000. The detergent in the composition can be an ionic, non-ionic, surfactant, cationic, anionic, zwitterionic, or amphoteric detergent, providing flexibility in formulation.

Furthermore, the composition may contain no more than certain specified concentrations of urea, be free of urea or guanidinium, and include additional components such as ionic salts, reducing agents, and proteases. The buffer in the composition can be phosphate, Tris, Bis-Tris, e-aminocaproic acid, or HEPES, with a pH range between 3.5 and 9.0. The aqueous solution may have a buffer concentration between 10 mM and 200 mM, offering a wide range of conditions for various applications. Overall, the patent application outlines a versatile composition with specific concentrations and components tailored for effective use in relevant processes.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies