Endologix has been granted a patent for a method of preparing a hydrogel using a stable dry powder mixture. The dry powder includes a straight chain polyethylene glycol and a thermally activated free radical initiator. The method involves combining the dry powder with a buffered aqueous solution and a solution of a branched polyethylene glycol to form a hydrogel. The dry powder mixture is stable at ambient conditions and has a particle size of 500 microns or less. GlobalData’s report on Endologix gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Endologix, Prosthetic cardiac valves was a key innovation area identified from patents. Endologix's grant share as of September 2023 was 51%. Grant share is based on the ratio of number of grants to total number of patents.

A patent granted for a method of preparing a hydrogel

Source: United States Patent and Trademark Office (USPTO). Credit: Endologix LLC

A recently granted patent (Publication Number: US11759553B2) describes a method for preparing a hydrogel using specific ingredients and techniques. The method involves combining separate amounts of a dry powder mixture, a buffered aqueous solution, an aqueous solution comprising a second prepolymer, and an initiator catalyst solution. The dry powder mixture, which contains a first prepolymer and a free radical initiator, is stable at ambient conditions and has a particle size of 500 microns or less. The first prepolymer is a straight chain polyethylene glycol, while the second prepolymer is a branched polyethylene glycol. The dry powder mixture is combined with the buffered aqueous solution to form a first mixture. Simultaneously, the second prepolymer solution is combined with the initiator catalyst solution to form a second mixture. Finally, the first and second mixtures are combined under suitable conditions to form the hydrogel.

The patent also includes variations of the method, such as different derivatizations of the straight chain polyethylene glycol and the branched chain polyethylene glycol. For example, the straight chain polyethylene glycol can be terminally derivatized with acrylate, methacrylate, vinyl, or substituted vinyl end groups. In one embodiment, it is terminally derivatized with two acrylate groups. Similarly, the branched chain polyethylene glycol can be terminally derivatized with three acrylate groups.

Furthermore, the patent mentions that the free radical initiator used in the method can be selected from a group consisting of amines, persulfates, or ferrous compounds.

Another aspect of the patent describes a method for preparing a dry powder mixture. This involves preparing a solution containing a prepolymer comprising a straight chain polyethylene glycol and a thermally activated free radical initiator, such as sodium persulfate, potassium persulfate, or ammonium persulfate. The solution is then dehydrated to form a dry powder that is stable at ambient conditions and has a particle size of 500 microns or less. Dehydration can be achieved through techniques like lyophilization or spray drying.

Overall, this patent provides a detailed method for preparing hydrogels using specific ingredients and techniques. The variations and options mentioned in the patent offer flexibility in tailoring the hydrogel properties for different applications.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.