Freenome had five patents in artificial intelligence during Q4 2023. Freenome Inc’s patents in Q4 2023 focus on improving the quality and accuracy of nucleic acid methylation sequencing for disease detection. The methods include minimally-destructive conversion techniques and specialized UMI adapters for better sequencing library quality. This results in greater accuracy and more complete methylation-state information, enabling higher quality feature generation for machine learning models and classifier development. GlobalData’s report on Freenome gives a 360-degreee view of the company including its patenting strategy. Buy the report here.
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Freenome grant share with artificial intelligence as a theme is 20% in Q4 2023. Grant share is based on the ratio of number of grants to total number of patents.
Recent Patents
Application: Methods and systems for high-depth sequencing of methylated nucleic acid (Patent ID: US20230323446A1)
The patent filed by Freenome Inc. focuses on methods and systems that aim to improve the quality and accuracy of nucleic acid methylation sequencing for disease detection. By utilizing minimally-destructive conversion methods and specialized UMI adapters, the sequencing libraries' quality is enhanced, leading to greater accuracy and more comprehensive methylation-state information. This, in turn, allows for the generation of higher quality features for machine learning models and classifier development, addressing current limitations of bisulfite-based methylation sequencing.
The patent claims outline a method for detecting or treating cancer in a subject by sequencing enriched nucleic acid samples at a depth of over 100X, utilizing unique molecular identifiers and minimally-destructive conversion techniques. The process involves comparing the nucleic acid sequences to a reference panel, identifying cancer based on the comparison, and subsequently detecting or treating the cancer. Additional claims detail specific aspects of the method, such as the use of cell-free DNA samples, duplex error correction, enzymatic conversion, and the inclusion of conversion-tolerant adapters. The patent also covers the programming of a computer to perform the sequencing and analysis steps outlined in the method, emphasizing the innovative approach to improving methylation sequencing for disease detection and treatment.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
