Illumina. has filed a patent for techniques related to motion feedback in imaging systems, achieving nanoscale control without high-resolution encoders. The claim describes a patterned flow cell with sample sites arranged in a periodic pattern with varying geometric parameters. GlobalData’s report on Illumina gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Illumina, Microfluidics automation was a key innovation area identified from patents. Illumina's grant share as of January 2024 was 40%. Grant share is based on the ratio of number of grants to total number of patents.

Patterned flow cell for sample sites with different geometric parameters

Source: United States Patent and Trademark Office (USPTO). Credit: Illumina Inc

A patterned flow cell for use in sequencing instruments has been described in a recently filed patent application (Publication Number: US20240033738A1). The flow cell comprises a functional layer with a first plurality of sample sites arranged in a periodic pattern, alternating with a second plurality of sample sites, each having different geometric parameters such as depth or diameter. The flow cell also includes features that reflect or fluoresce in the presence of specific wavelengths, aiding in imaging during scanning operations. The periodic intervals between the sample sites and features are carefully designed to optimize scanning efficiency and data acquisition.

Furthermore, the patent application details a sequencing instrument incorporating the patterned flow cell, with components like an imager sub-system, focusing sub-system, and controller for precise scanning and data acquisition processes. The instrument utilizes modulated intensity data from periodically spaced features on the flow cell to derive linear translation velocity and calibrate scanning operations. The geometric variations in the sample sites and features, along with their reflective properties, contribute to the instrument's ability to capture high-quality data efficiently. Overall, the patent application showcases innovative design elements aimed at enhancing the performance and accuracy of sequencing instruments through the use of patterned flow cells with strategically placed sample sites and features.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies