Illumina has been granted a patent for a composition involving a nanopore with nucleotides, a polymerase, and a tether for sequencing polynucleotides. The invention allows for accurate detection of nucleotide sequences based on complementary binding. GlobalData’s report on Illumina gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Illumina, Microfluidics automation was a key innovation area identified from patents. Illumina's grant share as of April 2024 was 39%. Grant share is based on the ratio of number of grants to total number of patents.

Nanopore composition for nucleotide sequencing

Source: United States Patent and Trademark Office (USPTO). Credit: Illumina Inc

A recently granted patent (Publication Number: US11970734B2) discloses a composition comprising a substrate with a nanopore extending through its first and second sides. The nanopore includes a constricting region with specific diameters, and a reporter region is located within this constricting region. The composition also involves an elongated body and tail region that may or may not extend beyond the second side of the substrate. Additionally, the polymerase present in the composition plays a crucial role in generating signal states, either electrical or optical, based on the successful incorporation of nucleotides into polynucleotides.

Furthermore, the patent describes a system incorporating the composition, along with measurement circuitry to measure current or flux states through the nanopore. This system aids in identifying specific nucleotides based on the current or flux state, as well as determining the complementarity of nucleotides in polynucleotides. The method outlined in the patent involves providing a substrate with a nanopore and constricting region, emphasizing the importance of specific diameters in the nanopore for optimal functionality. Overall, the patent focuses on innovative compositions, systems, and methods for nucleotide sequencing and analysis, highlighting the significance of nanopores and polymerases in these processes.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.