NanoString Technologies has developed a compact, mobile digital spatial profiling system for imaging regions-of-interest (ROIs) in tissue samples. The system includes UV light for photocleaving oligos off antibodies, a visible light source, and a personal mobile computing device for user interface. The system allows for precise imaging and analysis of tissue samples. GlobalData’s report on NanoString Technologies gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on NanoString Technologies, Personalized medicine biomarkers was a key innovation area identified from patents. NanoString Technologies's grant share as of May 2024 was 34%. Grant share is based on the ratio of number of grants to total number of patents.
Compact, mobile digital spatial profiling system for tissue imaging
A digital spatial profiling (DSP) system has been granted a patent (Publication Number: US12002572B2) that includes a housing containing components such as a power source, UV light source, visible light source for imaging, and a chamber with a slot for a tissue sample slide. The system also features a personal mobile computing device (PMD) with a camera sensor to image the tissue sample, photomasking means for selective illumination, optic means for directing light, and processing circuitry for image acquisition and user interaction. The PMD can be attached to the housing or chamber, offering flexibility in operation.
The system's photomasking means utilizes an LCD with a backlight, optics include condenser and objective lenses, and various technologies like DMD, LCoS, OLED, and more can be incorporated. The system allows for precise illumination resolution, field of view, and magnification, with additional capabilities for dark-field microscopy, bright-field microscopy, and other microscopy techniques. Fluid transport mechanisms, temperature sensors, and sealing means for maintaining a liquid environment over the tissue sample are also integrated. The method involves imaging the tissue sample, selecting regions of interest, and exposing them to UV light for cleaving oligos, enabling the collection of solution containing cleaved oligos. The patent also covers a computer-readable medium storing instructions for conducting the method's steps, enhancing the system's functionality and usability in spatial profiling applications.
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