Natera has patented a method for detecting cancer or chromosomal abnormalities in fetuses using over 200 SNPs within haploblocks. The composition includes a pool of tagged primers that specifically bind to different sequences near SNP loci associated with copy number variation in disorders. GlobalData’s report on Natera gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Natera, AI-assisted genome sequencing was a key innovation area identified from patents. Natera's grant share as of May 2024 was 27%. Grant share is based on the ratio of number of grants to total number of patents.
Improved method for detecting ploidy of chromosome regions
A recently granted patent (Publication Number: US11946101B2) discloses a composition comprising a pool of tagged primers, with 200 to 10,000 primers or primer pairs that specifically bind to different primer binding sequences near SNP loci. These primer binding sequences are predominantly located within haploblocks exhibiting copy number variation associated with a disorder or disease, with strong linkage disequilibrium among the SNP loci within each haploblock. The composition can range from 300 to 5,000 primers or primer pairs targeting SNP loci within haploblocks, with at least 95% of the primer binding sequences and SNP loci located within these haploblocks.
Moreover, the composition may include a polymerase and circulating free nucleic acids from an individual, particularly derived from blood, serum, plasma, or urine samples of a human subject, where the disorder or disease targeted is cancer. This innovative approach aims to provide a comprehensive tool for detecting genetic variations associated with specific disorders or diseases by targeting SNP loci within haploblocks, offering potential advancements in diagnostic and therapeutic strategies for conditions like cancer. The patent's detailed claims outline the specific parameters and variations of the composition, emphasizing the precision and efficiency of the primer pool in identifying genetic markers linked to various health conditions.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
