Pacific Biosciences of California has been granted a patent for engineered polymerases with modified motifs A and B, increasing accuracy in identifying bases in nucleic acids. The method involves forming a ternary complex with a fluorescently labeled test nucleotide, detecting the base, and incorporating the correct nucleotide. GlobalData’s report on Pacific Biosciences of California gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pacific Biosciences of California, Optoelectronic biosensors was a key innovation area identified from patents. Pacific Biosciences of California's grant share as of February 2024 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
Dna polymerase with increased accuracy in identifying bases
A recently granted patent (Publication Number: US11913038B2) discloses a method for identifying a base in a primed template nucleic acid using a ternary complex formed by contacting a primer-template nucleic acid hybrid with an engineered DNA polymerase and a test nucleotide with a fluorescent label. The polymerase, with specific amino acid substitutions, demonstrates increased accuracy in pairing nucleotides to template bases compared to a control polymerase. The method involves detecting the fluorescent label to identify the next template base and incorporating an unlabeled nucleotide complementary to the base into the primer.
Furthermore, the method includes steps to stabilize the ternary complex, prevent incorporation of the test nucleotide using a blocking group in the primer, and replace the polymerase for nucleotide incorporation. The polymerase's characteristics, such as stability, polymerization kinetic rates, and error rates, are crucial in ensuring accurate base identification. The polymerase's average error rate is specified for different sequencing cycles, emphasizing the importance of polymerase accuracy in sequencing processes. This patented method offers a precise and efficient approach to identifying bases in nucleic acids, with potential applications in various fields requiring accurate nucleotide sequencing.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
