Paul Hartmann has filed a patent for a method to assess the status of a patient’s wound. The method involves determining the concentration of inflammatory and bacterial markers in a wound sample, and assessing the wound’s status based on these markers. This method aims to provide a reliable and detailed assessment of wound status. GlobalData’s report on Paul Hartmann gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Paul Hartmann, Remote monitored dialysis machines was a key innovation area identified from patents. Paul Hartmann's grant share as of September 2023 was 56%. Grant share is based on the ratio of number of grants to total number of patents.
A recently filed patent (Publication Number: US20230250466A1) describes a method for assessing the status of a wound in a patient. The method involves determining the concentration of inflammatory markers and bacterial markers in a sample from the wound. These markers can indicate the presence of inflammation within the wound and the colonization of the wound with metabolically active bacteria. Based on the concentrations of these markers, the status of the wound can be assessed as either inflamed or not inflamed, and colonized with metabolically active bacteria or not colonized.
The patent claims also specify the specific inflammatory markers and bacterial markers that can be used in the method. The inflammatory markers include activated protein C, arginase, calprotectin, cathepsin G, interleukin-1 alpha, interleukin-1 beta, lysozyme, matrix metalloproteinase 2, matrix metalloproteinase 9, matrix metalloproteinase 13, myeloperoxidase, neutrophil elastase, soluble intercellular adhesion molecule-1, tumor necrosis factor alpha, uric acid, xanthine oxidase, and mixtures thereof. The bacterial markers include coagulase, enzymes such as alkaline phosphatase or nitrate reductase, metabolites such as acetoin, acetone, ammonia, nitrate, nitrite, and mixtures thereof, siderophores such as acinetobactin, aerobactin, baumannoferrin, enterobactin, fimsbactin, staphyloferrin A, staphyloferrin B, pyochelin, pyoverdine, salmochelin, yersiniabactin, and mixtures thereof, signaling molecules such as quorum sensing molecules like indole or autoinducer-2, and virulence factors such as alkaline protease, alpha-toxin, y-hemolysin, LasA protease, LasB elastase, LecA lectin, LukDE, LukGH (LukAB), panton-valentine-leukocidin (PVL), a phenol soluble modulin (PSM), pyocyanin, a rhamnolipid, and mixtures thereof.
The method also includes additional steps such as determining the pH value of the sample, which can indicate a poorly healing or non-healing wound, and assessing the need for anti-inflammatory or antibacterial treatment based on the status of the wound. The concentrations of the markers can be determined using various analytical methods, including enzymatic, immunological, colorimetric, fluorimetric, radioactive, spectrophotometric methods, or dipstick type tests.
The patent also describes a device for assessing the status of a wound, which includes means for determining the concentrations of inflammatory and bacterial markers and indicating the results. Additionally, a wound dressing is mentioned, which incorporates the device for wound assessment.
Overall, this patent presents a method and device for assessing the status of a wound based on the concentrations of inflammatory and bacterial markers. This can provide valuable information for determining the presence of inflammation and bacterial colonization in wounds, allowing for appropriate treatment decisions.
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