Seegene has filed a patent for a cartridge that detects a target analyte. The cartridge includes a sample containing part, a sample drawing part, and a sample flowing channel. The sample flows into a pipette tip through the sample flowing channel using negative pressure. GlobalData’s report on Seegene gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Seegene, AI-assisted drug screening was a key innovation area identified from patents. Seegene's grant share as of September 2023 was 30%. Grant share is based on the ratio of number of grants to total number of patents.
Cartridge for detecting a target analyte using negative pressure
A recently filed patent (Publication Number: US20230302446A1) describes a cartridge for detecting a target analyte. The cartridge includes a sample containing part, a sample drawing part, and a sample flowing channel that connects the two parts. The sample flows into a pipette tip from the sample containing part through the sample flowing channel using negative pressure delivered through the pipette tip.
The cartridge also includes a pipette tip support part in the sample drawing part, which supports the end of the pipette tip. The support part has a sloping surface, preferably conical, that slopes downwards towards a pipette tip support hole. The pipette tip support hole serves as the outlet of the sample flowing channel. When the pipette tip is inserted into or in close contact with the support hole, the inlet of the pipette tip and the inside of the sample drawing part are fluidly disconnected from each other. The negative pressure delivered through the pipette tip is directly delivered to the sample flowing channel in this state.
The sample flowing channel fluidly connects the lower part of the sample containing part with the lower part of the sample drawing part. The cartridge may also include a filter member in the sample containing part or the sample flowing channel. The filter member is spaced away from the bottom surface of the sample containing part and may be prepared as a one-way valve at the pipette tip entrance. When the pipette leaves the pipette tip entrance, the one-way valve is closed to disconnect the inside of the sample containing part from the outside.
Additionally, the cartridge may have a separation wall that divides the first chamber of the sample containing part and the second chamber of the sample drawing part. The sample flowing channel passes through or below the separation wall. A filter member may be disposed in front of the inlet of the sample flowing channel of the first chamber, and a spacer may support the filter member. The width of the sample flowing channel is smaller than the width of the separation wall, and the inlet of the sample flowing channel becomes narrower in the flow direction of the fluid.
In another embodiment, the cartridge includes a body part with a pretreatment area and a detection area. The pretreatment area has a plurality of wells for pretreating a sample, while the detection area is for detecting the presence of a target analyte in the pretreated sample. The body part includes a sample containing well, a sample drawing well, buffer wells, reagent wells, a processing well, and detection wells. The sample containing well and the sample drawing well are in fluid communication with each other via a sample flowing channel, and the sample flows directly into the pipette tip from the sample containing well using negative pressure delivered through the pipette tip.
Overall, this patent describes various embodiments of a cartridge for detecting a target analyte, providing improved sample flow and containment within the cartridge.
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