In March 2026, Swiss biotech AC Immune presented Phase I data including the first in vivo images of TDP-43 pathology in the human brain, detected using its first-in-class positron emission tomography (PET) tracer ACI-19626, at the International Conference on Alzheimer’s and Parkinson’s Disease in Denmark.

According to the company, the results indicate that ACI-19626 could have an important role to play in the early diagnosis of multiple neurogenerative diseases, with a clear path to precision medicine.

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In this episode, AC Immune’s group leader, Dr Tamara Seredenina, and Dr Francesca Capotosti, senior vice president of research, discuss the initial data and what’s next for the company.