Roche has launched a new fully automated protein melting application for its high-throughput, real-time PCR LightCycler 1536 instrument.
The new capability offers a high-throughput protein melting solution for US biotech, pharmaceutical markets, contract research organisations (CROs) and large academic research groups.
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With the new application, the fully automated platform enables life science researchers to perform thermal shift assays (TSAs) in 1536-well applications quickly and consistently.
According to the company, the capability makes the LightCycler 1536 instrument the first 1536-well PCR instrument capable of performing thermal shift assays.
Roche Life Science application support consultant Rama Badugu said: "Now researchers who currently run protein thermal shift assays on Roche’s LightCycler 480 instrument, using 96 or 384-well throughput, can also run these reactions on the LightCycler 1536 instrument.
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"That enables them to increase throughput, while reducing the amount of protein used in the reaction, which is a key benefit of the LightCycler platform."
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By GlobalDataThe LightCycler 1536 instrument is a rapid, high-throughput, plate-based real-time PCR amplification and detection system, and is designed based on the LightCycler 480 platform, which combines a high-performance optical unit and block cycler technology.
It is claimed to be the only plate-based real-time PCR instrument that generates 1,536 data points in a single PCR run in less than 50 minutes.
The system is also the first 1536-well plate-based real-time PCR platform that is capable of producing data for high-throughput gene expression profiling, thermal shift assays and high-throughput genotyping.
Therma-Base technology in LightCycler instruments allows for uniform temperature distribution across the block, without any intermediate hold times.
The company said LightCycler instruments can heat as quickly as 4.8°C per second, which improves speed and accuracy in protein melt results.
