Roche has launched a new fully automated protein melting application for its high-throughput, real-time PCR LightCycler 1536 instrument.
The new capability offers a high-throughput protein melting solution for US biotech, pharmaceutical markets, contract research organisations (CROs) and large academic research groups.
With the new application, the fully automated platform enables life science researchers to perform thermal shift assays (TSAs) in 1536-well applications quickly and consistently.
According to the company, the capability makes the LightCycler 1536 instrument the first 1536-well PCR instrument capable of performing thermal shift assays.
Roche Life Science application support consultant Rama Badugu said: "Now researchers who currently run protein thermal shift assays on Roche’s LightCycler 480 instrument, using 96 or 384-well throughput, can also run these reactions on the LightCycler 1536 instrument.
"That enables them to increase throughput, while reducing the amount of protein used in the reaction, which is a key benefit of the LightCycler platform."
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The LightCycler 1536 instrument is a rapid, high-throughput, plate-based real-time PCR amplification and detection system, and is designed based on the LightCycler 480 platform, which combines a high-performance optical unit and block cycler technology.
It is claimed to be the only plate-based real-time PCR instrument that generates 1,536 data points in a single PCR run in less than 50 minutes.
The system is also the first 1536-well plate-based real-time PCR platform that is capable of producing data for high-throughput gene expression profiling, thermal shift assays and high-throughput genotyping.
Therma-Base technology in LightCycler instruments allows for uniform temperature distribution across the block, without any intermediate hold times.
The company said LightCycler instruments can heat as quickly as 4.8°C per second, which improves speed and accuracy in protein melt results.