Bruker has announced a significant investment in Germany-based company RECIPE Chemicals + Instruments, which provides mass spectrometry-based diagnostic assay kits.

The transaction’s financial aspects remain undisclosed.

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The German company offers vendor-agnostic therapeutic drug monitoring (TDM) and in vitro diagnostic kits that are compatible with liquid chromatography-mass spectrometry (LC–MS)/MS, high-performance liquid chromatography (HPLC), and inductively coupled plasma mass spectrometry (ICP-MS) assays.

RECIPE’s managing director Dr Gernot Wolfram spearheads the company’s operations.

Bruker noted that the investment and partnership bolster its offerings in small-molecule clinical diagnostic assays through the integration of ClinMASS kits of RECIPE with Bruker’s EVOQ liquid chromatography triple-quadrupole mass spectrometers and with LC-TQ-MS systems from other manufacturers. 

Furthermore, both entities are working to launch chromatography-free (chrom-free) RECIPE ClinDART kits that will operate on the EVOQ-DART TQ systems, allowing transitions between traditional LC-TQ-MS techniques and the high-throughput ClinDART processes.

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The EVOQ-DART TQ system, in its chrom-free mode, provides throughput for multiplex assays without the need for chromatography while ensuring sensitivity and quantitation through triple-quad mass spectrometry selectivity and multiple-reaction monitoring (MRM) features.

The ClinDART platform enhances sustainability by decreasing solvent consumption by 95%, reducing expenses, and boosting productivity of labs.

It complements RECIPE’s ClinMASS LC-TQ assay offerings and aims to establish new benchmarks for high-throughput TDM, drug screening for abuse, and various other applications.

Bruker Applied Mass Spectrometry senior vice-president Jeffrey Zonderman said: “This majority investment aligns with our strategic vision for LC-TQ-MS assays, enhanced with novel chrom-free assays based on our proprietary DART technology to lead in clinical research and regulated TDM markets.

“The RECIPE ClinMASS and novel ClinDART assays, combined with LC or chrom-free EVOQ DART-TQ methods, are expected to offer unparalleled flexibility, throughput, and cost-effectiveness.”

In June 2024, Bruker launched the neofleX Imaging Profiler MALDI-TOF/TOF for mass spectrometry imaging applications.

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